| Semaglutide |
Metabolism and Fat Loss |
GLP-1 receptor agonist; mimics gut hormone |
Appetite suppression; manages insulin; neuroprotective; cardiovascular improvement |
FDA approved (for Diabetes/Obesity) |
Originally for Type 2 diabetes; prevents dementia in early research |
| Tirzepatide |
Metabolism and Fat Loss |
Dual GLP-1 and GIP receptor agonist |
30% reduction in fatty liver; unprecedented weight loss results |
FDA approved (for Diabetes/Obesity) |
GIP amplifies insulin sensitizing effects |
| Retatrutide |
Metabolism and Fat Loss |
Triple agonist (GLP-1, GIP, and Glucagon receptor) |
80% reduction in fatty liver; direct visceral fat loss; maintains metabolic rate in deficit |
Primarily based on animal/research studies (Pending market entry) |
Expected to be approved for diabetes, obesity, and knee osteoarthritis. Increases heart rate |
| AOD-9604 |
Metabolism and Fat Loss |
Fragment of growth hormone (lipolytic region) |
Fat mobilization; fat burning ‘finisher’ |
Primarily based on animal/research studies |
Does not affect blood sugar or growth; less effective for major weight loss; body quickly adapts to this. |
| BPC-157 |
Inflammation and Tissue Repair |
Upregulates growth factor receptors; makes tissues more sensitive to repair signals |
Heals tendons, ligaments, muscles, and gut; body protection |
Primarily based on animal/research studies |
Derived from stomach protein; stable in stomach; available in oral supplements, can flatten affect. |
| TB500 (Thymosin beta 4) |
Inflammation and Tissue Repair |
Promotes cellular migration by upregulating actin |
Acts as GPS for repair signals; recruits repair crews to injury sites, anti-inflammatory, pain. |
Primarily based on animal/research studies |
Synthetic version of naturally occurring peptide; often paired with BPC-157 |
| TA-1 (Thymosin alpha 1) |
Inflammation and Tissue Repair |
Immune modulating peptide; regulates immune response |
Helps immune system respond intelligently; treats conditions like hepatitis |
FDA approved (or approved in over 35 countries) |
Used for immune regulation rather than just boosting |
| GHK-Cu (GHK copper) |
Inflammation and Tissue Repair, including hair growth |
Influences over 4,000 genes; promotes collagen synthesis |
Calms inflammatory gene expression; resets tissue environment; skin health (glow), hair growth, youth |
Primarily based on animal/research studies |
Naturally occurring peptide; production drops with age, painful injection, in cremes/serums for topical use. |
| KPV |
Inflammation and Tissue Repair |
Inhibits NF-Kappa B (master switch for inflammation) |
Treats gut and skin inflammation; improves nutrient absorption/mood by reducing gut inflammation |
Primarily based on animal/research studies |
Fragment of alpha MSH; available as oral supplement; stable in stomach |
| Sermorelin |
Recovery / Growth Hormone |
Growth hormone releasing hormone (GHRH) analog; stimulates pituitary pulses |
Restores natural pulsatile GH release; aids repair and muscle protein synthesis |
FDA approved |
Works in a natural pulsatile pattern unlike synthetic HGH |
| Tesamorelin |
Recovery / Growth Hormone / Metabolism |
GHRH analog; targeted effect on visceral fat |
15-20% reduction in visceral fat; improves fatty acid oxidation |
FDA approved (for HIV-associated lipodystrophy) |
Stronger effect on visceral fat than other analogs |
| CJC-1295 |
Recovery / Growth Hormone |
Stimulates GHRH receptors; longer half-life than Sermorelin |
Muscle building; increases growth hormone output |
Primarily based on animal/research studies |
More potent than Sermorelin due to staying in the body longer |
| Ipamorelin |
Recovery / Growth Hormone |
Selective ghrelin mimetic (GHRP) |
Raises GH without significantly increasing cortisol or prolactin |
Primarily based on animal/research studies |
Considered more selective than Hexarelin, GHRP2, or GHRP6 |
| IGF-1 LR3 |
Recovery / Growth Hormone |
Synthetic version of IGF-1 with a longer half-life |
Drives muscle repair; cellular growth; bypasses the pituitary, lowers blood sugar |
Primarily based on animal/research studies |
Advanced tool; delivers end product directly; requires deep understanding of usage; long term cancer risk. |
| MOTS-c |
Fatigue / Mitochondrial |
Encoded by mitochondrial DNA; activates AMPK (fuel sensor) |
Increases glucose utilization; lowers insulin resistance; shifts cells to fatty acid oxidation, energy |
Primarily based on animal/research studies |
Mitochondrial derived signaling peptide; reduces inflammatory signals, careful of dose! Start very low dose; morning dose |
| SS-31 (Elamipretide) |
Fatigue / Mitochondrial |
Binds to cardiolipin to stabilize the inner mitochondrial membrane |
Protects mitochondrial structure; treats mitochondrial disease; improves energy production |
FDA approved (for specific mitochondrial disease) |
Not in source, expensive |
| Dihexa (DHEXA) |
Cognition, Focus |
Potentiates the HGF receptor to drive synaptogenesis (formation of new synaptic connections) 10 million times more potently than BDNF. |
Physically grows new neuron connections; enhances pattern recognition; improves processing speed and executive function; structural changes are permanent. |
Developed at Washington State University; has not reached mainstream medical practice due to lack of pharmaceutical incentive for trials. |
5mg orally daily for 14 days; take minimum 6-8 weeks off; has a 12-day half-life; run only after a foundation of other peptides is established. |
| Semax |
Focus / Cognition / Anxiety |
Increases Brain Derived Neurotrophic Factor (BDNF) |
Fertilizer for neurons; improves focus, clarity, and alertness; brings cortisol to baseline, neuro-protective, youthening |
Primarily based on animal/research studies (Developed in Russia) |
Administered via nasal mucosa (sniffing), HAIR LOSS, if used late in day, affects sleep |
| Semax (Cax/Seatax) |
Cognition, Focus, Recovery |
Increases Brain-Derived Neurotrophic Factor (BDNF) and boosts dopamine and serotonin activity in the prefrontal cortex. |
Drives neuroplasticity; enhances verbal fluency; improves learning speed and information retention. |
Developed in Russia in the 1980s; prescribed clinically there for stroke recovery and neuro-rehabilitation. |
1-2 nasal drops for 2-4 weeks followed by 2-4 weeks off; dose in the morning to drive full-day BDNF levels. |
| Dihexa |
Focus / Cognition |
Works on hepatocyte growth factor to c-Met pathway |
Promotes synapse formation; 10 million times more potent than BDNF |
Primarily based on animal/research studies |
Oral peptide; significant safety concerns regarding growth factor pathways; studied for Alzheimer’s |
| Selank (Sank/Slank) |
Anxiety, Stress, Cognition |
Derived from tuftsin; modulates the GABA system and upregulates BDNF and serotonin metabolism. Helps bring over-amplified cortisol back to normal |
Reduces anxiety and “mental friction” without sedation or dependency; stabilizes the stress response. Compared to Xanax without the sedation or addiction. |
Safety profile built on 40+ years of clinical trials and use. Primarily based on animal studies. |
300mcg intranasally split between morning and midday for 14 days; avoid late evening doses as it may be mildly stimulating. |
| Epitalon |
Longevity / Sleep |
Activates telomerase; restores pineal gland/melatonin cycles |
Resets circadian rhythm; lengthens telomeres (protective chromosome caps), youthening |
Primarily based on animal/research studies |
Intersection of sleep optimization and longevity research, do in short cycles (2 wks then off), expensive |
| Epitalon (Epelon) |
Longevity, Sleep, Recovery |
Synthetic tetrapeptide derived from the pineal gland that rebuilds telomere caps and stimulates the pineal gland. |
Reverses cellular aging; improves REM quality and vivid dreaming; raises baseline cognitive function. |
Studied for over 40 years by Soviet scientists. |
Not a daily driver; 1-5mg subcutaneous injection daily for 20 days; run twice per year; dose 30-60 minutes before bed. |
| Pinealon |
Sleep |
Works at gene expression level within pineal cells |
Normalizes melatonin synthesis; restores structure of pineal gland cells |
Primarily based on animal/research studies |
Improves circadian rhythm |
| Pinealon |
Recovery, Cognition, Focus, Sleep |
Tripeptide that reduces oxidative stress/damage in brain tissue and restores circadian rhythm signaling. |
Protects neurons from degradation; improves memory and recall; stabilizes HRV; eliminates the “2:00 p.m. cognitive wall”. |
Legal and classified as a “bioregulator” or “nootropic” in Russia; often demonized in Western culture. |
200mcg subcutaneous injection daily for 20 days; run 2-3 times per year; time in the evening. |
| DSIP (Delta Sleep Inducing Pept) |
Sleep |
Promotes delta wave (deep) sleep |
Significant physical recovery; increases time in deepest sleep stage |
Primarily based on animal/research studies |
Deep sleep is critical for growth hormone release and immune function |
| ARA-290 |
Recovery / Healing |
Addresses neuropathy |
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2-3 months to affect; expensive. |
| PT-141 |
Sexual function |
Stimulates sex drive in brain |
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Male and female use. Be careful with dose! Can take 3 hours or far more before effect. |
| Oxytocin |
Bonding |
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May do nothing |
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| Have an AI use this cheat sheet to enhance this spreadsheet: |
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| https://e.drsamrobbins.com/peptides/cheatsheet |
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| PROMPT FOR ADDING: |
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| give a CSV of all peptides mentioned. Headings: Peptide Name, Category ( choose from any of these and mix and match as needed: Metabolism and Fat Loss, Inflammation and Tissue Repair, Recovery, Growth Hormone, Metabolism, Fatigue, Mitochondrial, Focus, Cognition, Anxiety, Stress, Longevity, Sleep, Healing, Sleep, Sexual Function, Bonding), Biological Mechanisms, Primary Benefits, Regulatory Status, Safety or Usage Notes |
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